The energy metabolism of Schistosoma mansoni during its development in the hamster.

摘要: A detailed study was made of the changes in carbohydrate metabolism ofSchistosoma mansoni occurring during both penetration skin a hamster and subsequent development schistosome lung, liver, mesenteric veins host. During infection, within few hours transition occurs from fully aerobic to largely anaerobic energy metabolism. By 5 h postinfection, about 6% breakdown reactions Krebs cycle, whereas rest formation lactate. The contribution processes remains at this level until 3 weeks postinfection then gradually declines adult 2.5%. Measurement protein content developing schistosomes shows that an exponential growth over 15-day period after arrival liver (days 11–25 postinfection). parasites increases 100-fold, but despite change size, no major occur end-product pattern breakdown. We conclude rate oxygen diffusion into tissues is not limiting factor for limited may play role decreasing later stages maturation schistosomes.