Metabolic changes associated with the migration of the schistosomulum of Schistosoma mansoni in the mammal host.

摘要: A variety of measurements was made on small samples schistosomula recovered from the skin, lungs and hepatic portal system percutaneously infected mice, basis which development could be divided into a migration growth phase. The density schistosomula, estimated using Ficoll gradient, found not to vary significantly between Day 0 24 post-infection, having mean value 1.077. reduced weight measured by means Cartesian diver balance used in conjunction with estimate change wet schistosomula. Wet decline slightly during phase increase exponentially following arrival system. No nitrogen content detected but there rapid after rate oxygen consumption, respirometer, declined then increased worms lactic dehydrogenase activity migrating again, an exponential occurred entry It concluded that schistosomulum is semi-quiescent metabolic state, although it possesses ability take up nutrients undergoes morphological changes. Growth triggered unknown mechanism Examination various sets data suggests initiated 10 11 days post-infection most advanced