Impact of treatment of gastroesophageal reflux on obstructive sleep apnea-hypopnea syndrome.

摘要: Objectives: We test the hypothesis that treatment of gastroesophageal reflux disease (GERD) can improve obstructive sleep apnea-hypopnea syndrome (OSAHS). Metliods: One hundred forty-six patients with OSAHS underwent a complete history-taking, physical examination, and laboratory testing, including questions related to GERD symptoms. Full-night attended polysomnography, 24-hour wireless pH study at upper esophagus, snoring level evaluation, Epworth Sleepiness Scale, quality-of-life surveys were completed for each patient. Patients who tested positive treated esomeprazole magnesium 40 mg once daily 2 12 months. The was repeated, those elimination reevaluated by surveys, subjective data collection. Resutts: Forty-one single-dose esomeprazole, but repeat showed 9 had persistent GERD. In 29 phase normal findings, decreased from 9.7 ± 0.5 7.9 1.3 (p < .0001), Scale score 14.2 2.5 11.1 2.4 index 37.9 19.1 28.8 11.5 = .006), minimum saturation oxygen increased 84.1% 7.8% 86.9% 5.0% .055). Conclusions: Treatment significant impact on reduction index, snoring, daytime sleepiness. Elimination should be part comprehensive plan OSAHS.