Laryngopharyngeal manifestations of reflux: diagnosis and therapy.

摘要: Acid reflux--most often associated with heartburn--may also cause a wide range of laryngopharyngeal symptoms, including laryngitis and chronic cough. Symptoms reflux (LPR), like those gastrooesophageal disease, result from abnormal exposure tissues to acid refluxate. Deranged sensorimotor function the upper oesophageal sphincter appears play key role in aetiology LPR, but disease is not completely understood. Among significant long-term complications LPR are bronchopulmonary disorders, recurrent pneumonia, cough, or laryngitis, oral cavity disorders. It be risk factor for development laryngeal carcinoma. Diagnosis based on physical examination, medical history, results specific tests. At present, test choice diagnosis intraluminal pH monitoring. Barium contrast oesophagography, intraoesophageal perfusion challenge, flexible endoscopic evaluation swallowing sensory testing may used diagnosis. Treatment includes changes diet lifestyle, acid-suppressing therapy. The Therapeutic Working Party at First Multi-Disciplinary International Symposium Supraesophageal Complications Gastroesophageal Reflux Disease has recommended twice-daily dosing proton pump inhibitor as an initial therapy treatment continued between 4 weeks 6 months. Such been found highly effective resolving symptoms it prevent serious this condition.