Risk of symptomatic gallstones in women with severe obesity.

摘要: Although obesity is a well-recognized risk factor for gallstones, the excess risks associated with higher levels of and recent weight change are poorly quantified. We evaluated these issues in Nurses' Health Study. Among 90,302 women aged 34-59 y at baseline followed from 1980 to 1988, 2122 cases newly diagnosed symptomatic gallstones occurred during 607,104 person-years follow-up. From 1986, 488 unremoved were documented. observed striking monotonic increase gallstone disease obesity; body mass index (BMI) greater than 45 kg/m2 had sevenfold compared those whose BMI was less 24 kg/m2. Women 30 yearly incidence 1% or equal rate approximately 2%/y. Recent loss modestly increased after adjustment before loss. Current smoking an independent factor; 35 cigarettes/d relative 1.5 (95% CI 1.2-1.9).