Update of the tolerable upper intake level for vitamin D for infants.

摘要: Following a request from the European Commission, Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to revise tolerable upper intake level (UL) for vitamin D infants (≤ 1 year) set in 2012. From its literature review, Panel concluded that available evidence on daily risk of adverse health outcomes (hypercalciuria, hypercalcaemia, nephrocalcinosis abnormal growth patterns) cannot be used alone deriving UL infants. The Panel conducted meta-regression analysis collected data, derive dose-response relationship between supplemental mean achieved serum 25(OH)D concentrations. Considering concentration 200 nmol/L or below is unlikely pose infants, Panel estimated percentage reaching above this value at different intakes D. Based overall evidence, Panel kept 25 μg/day aged up 6 months 35 μg/day 6-12 months. Panel was also advise safety consumption infant formulae with an increased maximum content 3 μg/100 kcal (Commission Delegated Regulation (EU) 2016/127 repealing Directive 2006/141/EC 2020). For 4 months, assessment showed use containing may lead some receive without considering intake. 4-12 months, 95th percentile (high consumers) estimated foods fortified not vitamin D does exceed ULs,