Parathyroid Hormone, Parathyroid Hormone–Related Protein, and Calcitonin

摘要: Publisher Summary This chapter provides information on mechanism, structure, and function of parathyroid hormone (PTH), hormone-related protein (PTHrP), Calcitonin. The observations that intermittent administration PTH induces anabolic responses in the skeleton have led to development analogs for treatment osteoporosis. Like many growth factors or cytokines, PTHrP has been suggested functions, such as skeleton, mammary gland, placenta, smooth muscle cardiovascular system, teeth, bone homeostatis. Finally, far calcitonin is concerned, it a convenient serum tumor marker medullary thyroid carcinoma, can be used longitudinal monitoring patients signs recurrence progression after surgery. There considerable variability ability individual cancers produce calcitonin, so baseline levels drawn prior surgery are needed interpret results. effects osteoclast made useful agent calcium disorders.