Extracellular calcium sensing and signalling.
作者： Aldebaran M. Hofer , Edward M. Brown
DOI: 10.1038/NRM1154
关键词: Function (biology) 、 Receptor 、 Extracellular 、 Cell type 、 Calcilytic 、 Cell biology 、 Juxtacrine signalling 、 Calcium 、 Biology 、 NPS-2143
摘要: Ca2+ is well established as an intracellular second messenger. However, the molecular identification of a detector for extracellular — calcium-sensing receptor has opened up possibility that might also function messenger outside cells. Information about local concentration conveyed to interior many cell types through this unique G-protein-coupled receptor. Here, we describe new emerging concepts concerning signalling Ca2+, with particular emphasis on
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