Calcium-Sensing Receptor in Cardiac Physiology

作者: Sanela Smajilovic , Jacob Tfelt-Hansen , Naibedya Chattopadhyay

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摘要: Calcium is a crucial signal molecule in the cardiovascular system. (Ca 2+ ) acts as second messenger via changes intracellular Ca levels through actions of calcium channels and pumps. However, it now well known that may also be an extracellular first G-protein-coupled receptor senses ex- tracellular concentration, calcium-sensing (CaR). The CaR one key players cal- cium homeostasis, but besides being expressed major organs involved parathyroid gland, kidney intestine, has been found to functionally other tissues. Although several studies demonstrated heart blood vessels, exact roles system still re- main elucidated. This review will summarize current knowledge on expression possible functions cardiac tissue.

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