The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test- A Rapid Office Based Assay Test for the Detection of Colorectal Cancer

摘要: Background M2 pyruvate kinase (M2PK) is an oncoprotein secreted by colorectal cancers in stools. This the first report on accuracy of a rapid stool test detection cancer (CRC). Objective To determine sensitivity, specificity and positive negative predictive value rapid, point care M2 PK- M2PK Quick. Methods Consecutive cases endoscopically diagnosed histological proven CRC were recruited. Stools collected patients tested with immunochromatographic Quick Test (Schebo Biotech AC, Giessen, Germany). Controls consecutively chosen from without any significant or gastrointestinal disease undergoing colonoscopy. was staged according to AJCC staging manual (7th Edition) location tumor defined as proximal distal. Results The specificity, value, overall were: 93%, 97.5%, 94.9%, 96.5% 96.0% respectively. The for tumors significantly lower compared distal tumors. No differences seen between different stages tumor. Conclusions M2-PK Quick, point-of-care highly accurate CRC. It easy convenient perform useful diagnostic clinical practice setting.