Measurement of fecal pyruvate kinase type M2 (tumor M2-PK) concentrations in patients with gastric cancer, colorectal cancer, colorectal adenomas and controls.

摘要: Background: The determination of Tumor M2 Pyruvate Kinase (Tumor M2-PK) in EDTA plasma has been described as a tumor marker variety different types. Since most GI tumors grow intraluminally, it appeared interesting to determine whether M2-PK is detectable the feces patients. Materials and Methods: Measurements were performed with commercially available ELISA (ScheBo®○ Biotech AG, Giessen, Germany) modified for fecal analysis. Samples controls, cancer adenoma patients tested. Results: Fecal concentrations could be quantified. A significant difference between controls was found. highest observed colorectal cancer. However, not 5 Conclusion: measurement might provide an screening tool Further studies comparing stool occult blood are progress.