The cells and peripheral representation of sodium taste in mice
作者： Jayaram Chandrashekar , Christina Kuhn , Yuki Oka , David A. Yarmolinsky , Edith Hummler
DOI: 10.1038/NATURE08783
关键词: Taste 、 CALHM1 、 Population 、 Amiloride 、 Transgene 、 Cell signaling 、 Sodium 、 Chemistry 、 Epithelial sodium channel 、 Biochemistry 、 Cell biology
摘要: Salt taste in mammals can trigger two divergent behavioural responses. In general, concentrated saline solutions elicit robust behavioural aversion, whereas low concentrations of NaCl are typically attractive, particularly after sodium depletion,,,,. Notably, the attractive salt pathway is selectively responsive to sodium and inhibited by amiloride, whereas the aversive one functions as a non-selective detector for a wide range of salts,,,,,,. Because amiloride is a potent inhibitor of the epithelial sodium channel (ENaC), ENaC has been …
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