Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones.

摘要: The nigra substantia pars compacta (SNc) and reticulata (SNr) form two major basal ganglia components with different functional roles. SNc dopaminergic (DA) neurones are vulnerable to cell death in Parkinson's disease, NMDA receptor activation is a potential contributing mechanism. We have investigated the sensitivity of whole-cell synaptic responses intracellular ATP GTP application SNr from rats on postnatal day (P) 7 P28. Both current density (pA/pF) desensitization prolonged or repeated were greater than SNc. When levels not supplemented, administration desensitized P7 DA but at At P28, more neurones, without added ATP. Responses brief applications currents sensitive inclusion pipette solution. To investigate these differences between SNr, NR2 subunit-selective antagonists tested. inhibited by ifenprodil (10 microM) UBP141 (4 microM), Zn(2+) (100 nm), both SNc, suggesting that express similar subunits; NR2B NR2D, NR2A. response properties may be caused modulation and/or trafficking. vulnerability correlated subtypes, could part related inadequate desensitization.