Advances in genomics, transcriptomics and proteomics of toxin‐producing cyanobacteria

作者: Paul M. D'Agostino , Jason N. Woodhouse , A. Katharina Makower , Anna C. Y. Yeung , Sarah E. Ongley

DOI: 10.1111/1758-2229.12366

关键词: TranscriptomeBiologyToxinComputational biologyMetaproteomicsBiotechnologyMetagenomicsGenomeGeneGenomicsProteomics

摘要: A common misconception persists that the genomes of toxic and non-toxic cyanobacterial strains are largely conserved with exception presence or absence genes responsible for toxin production. Implementation -omics era technologies has challenged this paradigm, comparative analyses providing increased insight into differences between same species. The implementation genomic, transcriptomic proteomic approaches revealed distinct profiles toxin-producing strains. Further, metagenomics metaproteomics highlight genomic potential functional state bloom events over time. In review, we how these have shaped our understanding complex relationship molecules, their producers environment at large within which they persist.

参考文章(74)
Saw Yen Ow, Phillip C. Wright, High‐Throughput Cyanobacterial Proteomics: Systems‐Level Proteome Identification and Quantitation Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches. pp. 645- 661 ,(2011) , 10.1002/9781118010518.CH69
Elke Dittmann, Thomas Börner, Hans von Döhren, Melanie Kaebernick, Marcel Erhard, Brett A. Neilan, Christian Scheler, Altered expression of two light-dependent genes in a microcystin-lacking mutant of Microcystis aeruginosa PCC 7806. Microbiology. ,vol. 147, pp. 3113- 3119 ,(2001) , 10.1099/00221287-147-11-3113
Jiangxin Wang, Lei Chen, Zixi Chen, Weiwen Zhang, RNA-seq based transcriptomic analysis of single bacterial cells Integrative Biology. ,vol. 7, pp. 1466- 1476 ,(2015) , 10.1039/C5IB00191A
Morgan M Steffen, Stephen P Dearth, Brian D Dill, Zhou Li, Kristen M Larsen, Shawn R Campagna, Steven W Wilhelm, Nutrients drive transcriptional changes that maintain metabolic homeostasis but alter genome architecture in Microcystis The ISME Journal. ,vol. 8, pp. 2080- 2092 ,(2014) , 10.1038/ISMEJ.2014.78
Matthias Kopf, Stephan Klähn, Ingeborg Scholz, Wolfgang R. Hess, Björn Voß, Variations in the non-coding transcriptome as a driver of inter-strain divergence and physiological adaptation in bacteria Scientific Reports. ,vol. 5, pp. 9560- 9560 ,(2015) , 10.1038/SREP09560
Steven W. Wilhelm, Gregory L. Boyer, Healthy competition Nature Climate Change. ,vol. 1, pp. 300- 301 ,(2011) , 10.1038/NCLIMATE1202
Chee Sian Gan, Kenneth F. Reardon, Phillip C. Wright, Comparison of protein and peptide prefractionation methods for the shotgun proteomic analysis of Synechocystis sp. PCC 6803. Proteomics. ,vol. 5, pp. 2468- 2478 ,(2005) , 10.1002/PMIC.200401266
Dongmei Yue, Yuke Peng, Qian Yin, Lin Xiao, Proteomic analysis of Microcystis aeruginosa in response to nitrogen and phosphorus starvation Journal of Applied Phycology. ,vol. 27, pp. 1195- 1204 ,(2015) , 10.1007/S10811-014-0405-4
Trine B Rounge, Thomas Rohrlack, Ave Tooming-Klunderud, Tom Kristensen, Kjetill S Jakobsen, None, Comparison of Cyanopeptolin Genes in Planktothrix, Microcystis, and Anabaena Strains: Evidence for Independent Evolution within Each Genus Applied and Environmental Microbiology. ,vol. 73, pp. 7322- 7330 ,(2007) , 10.1128/AEM.01475-07
Annick Méjean, Stéphane Mann, Thomas Maldiney, Gaëlle Vassiliadis, Olivier Lequin, Olivier Ploux, Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline. Journal of the American Chemical Society. ,vol. 131, pp. 7512- 7513 ,(2009) , 10.1021/JA9024353