Functional characterization of the 19q12 amplicon in grade III breast cancers
作者： Rachael Natrajan , Alan Mackay , Paul M Wilkerson , Maryou B Lambros , Daniel Wetterskog
DOI: 10.1186/BCR3154
关键词: Cancer research 、 Cyclin E 、 Comparative genomic hybridization 、 Biology 、 Gene duplication 、 Cyclin E1 、 Molecular pathology 、 Locus (genetics) 、 Amplicon 、 Molecular biology 、 Breast cancer
摘要: Introduction The 19q12 locus is amplified in a subgroup of oestrogen receptor (ER)-negative grade III breast cancers. This amplicon comprises nine genes, including cyclin E1 (CCNE1), which has been proposed as its 'driver'. The aim this study was to identify the genes within whose expression required for survival cancer cells harbouring their amplification.
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