An immunoelectrochemical platform for the biosensing of ‘Cocaine use’
作者： Tulay Yilmaz Sengel , Emine Guler , Z.Pinar Gumus , Ebru Aldemir , Hakan Coskunol
DOI: 10.1016/J.SNB.2017.02.087
关键词: Chemistry 、 Cocaine use 、 Analyte 、 Chromatography 、 Benzoylecgonine 、 Nanotechnology 、 Electrochemical detection 、 Surface modification 、 Biosensor 、 Macromonomer 、 Glassy carbon electrode
摘要: Abstract In the present work, we demonstrate a novel surface design by combination of benzoylecgonine (BE) antibody and poly- l -phenylalanine bearing electroactive macromonomer (EDOT-BTDA-PPhe). This system served as an electro-immunosensor platform for analysis cocaine use detecting both BE cocaine. To construct immunosensor, glassy carbon electrode was covered with EDOT-BTDA-PPhe. Subsequently, immobilized on polypeptide chains. The modifications were confirmed electrochemical techniques. immunosensor used detection evidence drug addiction. For analytes, linearity obtained between 0.5–25 μM. Finally, proposed successfully employed synthetic biological fluids.
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