Human Immunodeficiency Virus Type 2 Infection Associated with AIDS in West Africa
作者： François Clavel , Kamal Mansinho , Sophie Chamaret , Denise Guetard , Veronique Favier
DOI: 10.1056/NEJM198705073161903
关键词: Immunology 、 Viral disease 、 Retrovirus 、 Acquired immunodeficiency syndrome (AIDS) 、 Population 、 Antibody 、 Immunopathology 、 Virology 、 Immunity 、 Virus 、 Medicine
摘要: We recently reported the isolation of a new retrovirus, termed human immunodeficiency virus type 2 (HIV-2), from two West African patients with acquired syndrome (AIDS). This is related to but distinct well-characterized AIDS 1 (HIV-1). report here evidence infection HIV-2 in 30 patients, almost all Africa. Seventeen them had clinical indistinguishable (7 these 17 died). Others either AIDS-related complex or no HIV-related symptoms. All serum antibodies reacting an indirect immunofluorescence assay. tested contained envelope glycoprotein immunoprecipitation Cross-reactivity HIV-1 was detected minority and varied according assay used. Retroviral isolates were obtained blood lymphocytes 11 identified as by nucleic acid hybridization; none hybridized probe. These findings indicate that some cases Africa may be caused HIV-2, extent spread this its correlates will require careful epidemiologic investigation.
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