Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
作者： Yuliya S Nikolova , Karestan C Koenen , Sandro Galea , Chiou-Miin Wang , Marianne L Seney
DOI: 10.1038/NN.3778
关键词: Human brain 、 Genotype 、 Neuroscience 、 Amygdala 、 Gene 、 Serotonin Plasma Membrane Transport Proteins 、 Internal medicine 、 Serotonin transporter 、 Endocrinology 、 DNA methylation 、 Biology 、 Epigenetics
摘要: We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted threat-related amygdala reactivity decreased mRNA expression postmortem tissue. These patterns were independent functional genetic variation same region. Furthermore, association with was replicated a second cohort robust both sampling methods age.
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