Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress.
作者： Xi Liu , Wei Cao , Jia Qi , Qing Li , Min Zhao
DOI: 10.1080/10715762.2018.1500021
关键词: Oxidative stress 、 Pharmacology 、 Renal fibrosis 、 Kidney 、 Podocyte 、 Nephropathy 、 Reactive oxygen species 、 Medicine 、 Leonurine 、 Acute kidney injury
摘要: Leonurine, a major bioactive component from Herba Leonuri, shows therapeutic potential in several diseases, including diabetes, cardiovascular disease, bovine mastitis and depression. In kidney, it was reported that leonurine performing protective effect both acute kidney injury renal fibrosis mice models. The aim of this study is to investigate the podocyte injury. model adriamycin (ADR) -induced nephropathy, application significantly prevented early damage, macrophage infiltration proteinuria. Meanwhile, suppressed ADR-induced reactive oxygen species (ROS) production. Consistent vivo results, ROS production cultured human podocytes. All these results suggested might suppress via inhibiting oxidative stress. Leonurine be novel drug for prevention glomerular diseases.
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