The influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor
作者： J. Vertomrnen , R. Kinget
DOI: 10.3109/03639049709148480
关键词: Particle size 、 Microcrystalline cellulose 、 Variables 、 Powder mixture 、 Composite material 、 Granulation 、 Particle-size distribution 、 Pellets 、 Friability 、 Mathematics
摘要: AbstractA factorial-designed study has been performed to investigate the effect of two formulation variables and three processing on size, size distribution, friability pellets made in a rotary processor by wet granulation technique. The first are microcrystalline cellulose content ratio amount added water powder mixture; latter rotor speed, spheronization time after addition, addition rate. Both have major influence pellet percentage loss weight test. With exception time, increasing an independent variable results wider distribution. technique judged be critical However, if all fully controlled, rather good reproducibility can obtained
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