In vitro activity of nonoxynol 9 on HeLa 229 cells and primary monkey cervical epithelial cells infected with Chlamydia trachomatis.

摘要: Nonoxynol 9 (non-9) is the active ingredient in a wide variety of vaginal contraceptive preparations. The manufacturer recommendation for optimal practice repeated application every 6 h. We studied vitro activity non-9 against Chlamydia trachomatis (E/UW-5/Cx) and its toxicity HeLa 229 cells monkey cervical epithelial cells. With contact time h, was toxic to at concentrations 50 micrograms/ml or greater 100 greater. Inhibitory effects on extracellular chlamydiae were observed Inhibition intracellular growth nontoxic concentration micrograms/ml. Our studies show that has antichlamydial activity. However, owing vitro, prolonged use vivo should be further studied.