Nodular pulmonary amyloidosis with spontaneous fatal blood aspiration

摘要: Amyloidosis is a multisystem disease, which characterized by the extracellular deposition of insoluble abnormal fibrils. Histological and subsequent immunohistochemical examinations are necessary for determination diagnosis classification amyloid type. The most common systemic variant immunoglobulin-derived light chain (AL) amyloidosis. However, local or organ-limited AL amyloidosis can occur. Isolated pulmonary rare condition frequently an incidental finding at chest scans during autopsy. Generally, it associated with benign prognosis. Here, we present two fatal cases, in cause death was asphyxiation due to severe blood aspiration. During autopsy, several nodules were found lungs. Based on histological analysis, isolated nodular lambda made. Amyloid also vessels, lead fragility finally hemorrhage.