Using DRS during breast conserving surgery: Identifying robust optical parameters and influence of inter-patient variation

摘要: Successful breast conserving surgery consists of complete removal the tumor while sparing healthy surrounding tissue. Despite currently available imaging and margin assessment tools, recognizing tissue at a resection during is challenging. Diffuse reflectance spectroscopy (DRS), which uses light for characterization, can potentially guide surgeons to prevent positive margins. However, inter-patient variation changes in physiology occurring might hamper this light-based technology. Here we investigate how status (in vivo vs ex vivo) affect performance DRS optical parameters. In measurements 45 cancer patients were obtained quantified with an analytical model acquire The parameter representing ratio between fat water provided best discrimination normal tissue, area under receiver operating characteristic curve 0.94. There was no substantial influence other patient factors such as menopausal on measurements. Contrary expectations, normalization parameters did not improve discriminative power. Furthermore, taken significantly different from vivo. These findings indicate that robust technology detection surgery.