Neuroanatomical basis of paroxysmal sympathetic hyperactivity: a diffusion tensor imaging analysis.

摘要: Paroxysmal sympathetic hyperactivity (PSH) is observed in a sub-set of patients with moderate-to-severe traumatic brain injury (TBI). The neuroanatomical basis PSH poorly understood. It hypothesized that linked to changes connectivity within the central autonomic network. Retrospective analysis from multi-centre, prospective cohort study Methods and procedures: Adult who were <3 weeks after severe TBI enrolled screened for using standard definition. Patients underwent multimodal MRI, which included quantitative diffusion tensor imaging. Principal component (PCA) was used resolve set tracts into components. Ability predict evaluated via area under receiver operating characteristic (AUROC) tree-based classification analyses. Among 102 patients, 16 met criteria PSH. first principle significantly associated (p = 0.024, AUROC = 0.867) status even controlling age admission GCS. In tree analysis, age, GCS decreased FA splenium corpus callosum right posterior limb internal capsule discriminated vs no an AUROC 0.933. Disconnection involving may play role pathogenesis or expression