Different Combinations of Glucose Tolerance and Blood Pressure Status and Incident Diabetes, Hypertension, and Chronic Kidney Disease.
作者： Arash Derakhshan , Farideh Bagherzadeh‐Khiabani , Banafsheh Arshi , Azra Ramezankhani , Fereidoun Azizi
关键词: Type 2 Diabetes Mellitus 、 Prehypertension 、 Internal medicine 、 Cardiology 、 Hazard ratio 、 Endocrinology 、 Kidney disease 、 Blood pressure 、 Prediabetes 、 Population 、 Medicine 、 Diabetes mellitus
摘要: Background The impact of different combinations glucose tolerance and blood pressure status on the development type 2 diabetes mellitus (T2DM), hypertension (HTN), chronic kidney disease (CKD) still needs to be investigated. Methods Results A total 12 808 Iranian adults aged ≥20 years were included in 3 separate analyses investigate incidence T2DM, HTN, CKD. Multivariate Cox proportional hazard models used calculate ratios (95% CI). During a median follow‐up >10 years, overall rate for CKD was 12.2, 29.8, 24.8 per 1000 person‐years. For incident considering normal tolerance/normal as reference, prediabetes (PreDM)/HTN had highest risk (hazard ratio: 7.22 [5.71–9.12]) while PreDM/normal also showed significant (5.58 [4.41–7.05]). Furthermore, PreDM/HTN higher than ( P =0.06). In addition, PreDM/ marginally factor HTN tolerance/prehypertension predictor T2DM. Conclusions Presence associated with increased T2DM among PreDM population; however, dysglycemia did not increase individuals prehypertension. CKD, intensive management rather their predisease states, should considered.
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