Recent advances on the encoding and selection methods of DNA-encoded chemical library.

作者: Bingbing Shi , Yu Zhou , Yiran Huang , Jianfu Zhang , Xiaoyu Li

DOI: 10.1016/J.BMCL.2016.12.025

关键词: Selection (genetic algorithm)Encoding (memory)BioinformaticsDrug discoveryChemical libraryCombinatorial Chemistry TechniquesDNA-encoded chemical libraryChemical biologySmall Molecule LibrariesBiologyComputational biology

摘要: … The original concept of encoding chemical library with DNA … to use DNA molecules as tags to encode peptide synthesis … 10 6 heptapeptide library encoded by DNA tags on polystyrene …

参考文章(201)
Christina Greenwood, David Ruff, Sara Kirvell, Gemma Johnson, Harvinder S. Dhillon, Stephen A. Bustin, Proximity assays for sensitive quantification of proteins Biomolecular Detection and Quantification. ,vol. 4, pp. 10- 16 ,(2015) , 10.1016/J.BDQ.2015.04.002
Alexandre Novoa, Nicolas Winssinger, DNA display of glycoconjugates to emulate oligomeric interactions of glycans. Beilstein Journal of Organic Chemistry. ,vol. 11, pp. 707- 719 ,(2015) , 10.3762/BJOC.11.81
Alexander Lee Satz, Jianping Cai, Yi Chen, Robert Goodnow, Felix Gruber, Agnieszka Kowalczyk, Ann Petersen, Goli Naderi-Oboodi, Lucja Orzechowski, Quentin Strebel, DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries Bioconjugate Chemistry. ,vol. 26, pp. 1623- 1632 ,(2015) , 10.1021/ACS.BIOCONJCHEM.5B00239
Raphael M. Franzini, Stefan Biendl, Gediminas Mikutis, Florent Samain, Jörg Scheuermann, Dario Neri, “Cap-and-Catch” Purification for Enhancing the Quality of Libraries of DNA Conjugates ACS Combinatorial Science. ,vol. 17, pp. 393- 398 ,(2015) , 10.1021/ACSCOMBSCI.5B00072
Hongfeng Deng, Jingye Zhou, Flora S. Sundersingh, Jennifer Summerfield, Don Somers, Jeffrey A. Messer, Alexander L. Satz, Nicolas Ancellin, Christopher C. Arico-Muendel, Katie L. (Sargent) Bedard, Arthur Beljean, Svetlana L. Belyanskaya, Ryan Bingham, Sarah E. Smith, Eric Boursier, Paul Carter, Paolo A. Centrella, Matthew A. Clark, Chun-wa Chung, Christopher P. Davie, Jennifer L. Delorey, Yun Ding, G. Joseph Franklin, LaShadric C. Grady, Kenny Herry, Clare Hobbs, Christopher S. Kollmann, Barry A. Morgan, Laura J. (Pothier) Kaushansky, Quan Zhou, Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library. ACS Medicinal Chemistry Letters. ,vol. 6, pp. 919- 924 ,(2015) , 10.1021/ACSMEDCHEMLETT.5B00179
Yun Ding, Heather O’Keefe, Jennifer L. DeLorey, David I. Israel, Jeffrey A. Messer, Cynthia H. Chiu, Steven R. Skinner, Rosalie E. Matico, Monique F. Murray-Thompson, Fan Li, Matthew A. Clark, John W. Cuozzo, Christopher Arico-Muendel, Barry A. Morgan, Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT). ACS Medicinal Chemistry Letters. ,vol. 6, pp. 888- 893 ,(2015) , 10.1021/ACSMEDCHEMLETT.5B00138
Andrew B. MacConnell, Patrick J. McEnaney, Valerie J. Cavett, Brian M. Paegel, DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis. ACS Combinatorial Science. ,vol. 17, pp. 518- 534 ,(2015) , 10.1021/ACSCOMBSCI.5B00106
Chun Guo, Christopher P. Watkins, Ryan Hili, Sequence-Defined Scaffolding of Peptides on Nucleic Acid Polymers. Journal of the American Chemical Society. ,vol. 137, pp. 11191- 11196 ,(2015) , 10.1021/JACS.5B07675
Edgar R. Wood, Randy Bledsoe, Jing Chai, Philias Daka, Hongfeng Deng, Yun Ding, Sarah Harris-Gurley, Luz Helena Kryn, Eldridge Nartey, James Nichols, Robert T. Nolte, Ninad Prabhu, Cecil Rise, Timothy Sheahan, J. Brad Shotwell, Danielle Smith, Vince Tai, J. David Taylor, Ginger Tomberlin, Liping Wang, Bruce Wisely, Shihyun You, Bing Xia, Hamilton Dickson, The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. Journal of Biological Chemistry. ,vol. 290, pp. 19681- 19696 ,(2015) , 10.1074/JBC.M115.653113
Sofia Barluenga, Nicolas Winssinger, PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions. Accounts of Chemical Research. ,vol. 48, pp. 1319- 1331 ,(2015) , 10.1021/ACS.ACCOUNTS.5B00109