Use of Electron Microscopy in Core Biopsy Diagnosis of Oncocytic Renal Tumors
作者： N. B. Johnson , M. M. Johnson , M. K. Selig , G. P. Nielsen
DOI: 10.3109/01913121003725713
关键词: Kidney 、 Chromophobe cell 、 Pathology 、 Core biopsy 、 Medicine 、 Chromophobe Renal Cell Carcinoma 、 Ultrastructure 、 Oncocytoma 、 Biopsy 、 Electron microscope
摘要: The distinction between oncocytoma and chromophobe renal cell carcinoma, important clinically, may be challenging, especially as the tissue sample size decreases. Ancillary studies can helpful, although subject to interpretation variability. aim of this study was examine value electron microscopy in differentiating carcinoma on formalin fixed paraffin embedded needle core biopsies. Twenty biopsies were evaluated. Despite fixation embedding, classic ultrastructural features these neoplasms retained, revealing 80% sensitivity 100% specificity by initial work-up.
informahealthcare.com参考文章(26)
Brian F. Skinnider, Edward C. Jones, Renal oncocytoma and chromophobe renal cell carcinoma. A comparison of colloidal iron staining and electron microscopy. American Journal of Clinical Pathology. ,vol. 111, pp. 796- 803 ,(1999) , 10.1093/AJCP/111.6.796
A. Vieillefond, J. C. Fournet, R. Bouvier, M. Wassef, P. Gros, A. Fontaine, J. P. Saint-Andre, B. Cochand-Priollet, A. Lesourd, M. Toublanc, J. Bougaran, S. Deslignieres, M. C. Dauge-Geffroy, L. Groleau, V. Molinie, Renal chromophobe cell carcinoma and oncocytoma. A comparative morphologic, histochemical, and immunohistochemical study of 124 cases. Archives of Pathology & Laboratory Medicine. ,vol. 121, pp. 1081- 1086 ,(1997)
Teh Bt, Yang Xj, Adley Bp, Sugimura J, Papavero, Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Analytical and Quantitative Cytology and Histology. ,vol. 28, pp. 228- 236 ,(2006)
Scott R. Granter, Andrew A. Renshaw, Fine-needle aspiration of chromophobe renal cell carcinoma. Analysis of six cases. Cancer. ,vol. 81, pp. 122- 128 ,(1997) , 10.1002/(SICI)1097-0142(19970425)81:2<122::AID-CNCR6>3.0.CO;2-U
Jing Liu, Christina V. Fanning, Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies. Cancer. ,vol. 93, pp. 390- 397 ,(2001) , 10.1002/CNCR.10141
Beata A. Wiatrowska, Maureen F. Zakowski, Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma: comparison of cytomorphologic features. Cancer. ,vol. 87, pp. 161- 167 ,(1999) , 10.1002/(SICI)1097-0142(19990625)87:3<161::AID-CNCR10>3.0.CO;2-I
Xavier Leroy, Donatien Moukassa, Marie-Christine Copin, Fabien Saint, Etienne Mazeman, Bernard Gosselin, Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma. European Urology. ,vol. 37, pp. 484- 487 ,(2000) , 10.1159/000020172
Paolo Cossu Rocca, Matteo Brunelli, Stefano Gobbo, Albino Eccher, Emma Bragantini, Maria M Mina, Vincenzo Ficarra, Filiberto Zattoni, Alberto Zamò, Maurizio Pea, Aldo Scarpa, Marco Chilosi, Fabio Menestrina, Franco Bonetti, John N Eble, Guido Martignoni, Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Modern Pathology. ,vol. 20, pp. 722- 728 ,(2007) , 10.1038/MODPATHOL.3800828
Kohei Shomori, Yoji Nagashima, Naoto Kuroda, Ami Honjo, Yoshiyuki Tsukamoto, Naruo Tokuyasu, Noritaka Maeta, Keiko Matsuura, Naoki Hijiya, Shinji Yano, Shigeo Yokoyama, Hisao Ito, Masatsugu Moriyama, ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas Modern Pathology. ,vol. 20, pp. 199- 207 ,(2007) , 10.1038/MODPATHOL.3800730
Satish K. Tickoo, Mahul B. Amin, Richard J. Zarbo, Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining. The American Journal of Surgical Pathology. ,vol. 22, pp. 419- 424 ,(1998) , 10.1097/00000478-199804000-00005