Prospective Evaluation of 99mTc-sestamibi SPECT/CT for the Diagnosis of Renal Oncocytomas and Hybrid Oncocytic/Chromophobe Tumors

摘要: Abstract Nuclear imaging offers a potential noninvasive means of determining the histology renal tumors. The aim this study was to evaluate accuracy technetium-99m ( 99m Tc)–sestamibi single-photon emission computed tomography/x-ray tomography (SPECT/CT) for differentiation oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs) from other tumor histologies. In total, 50 patients with solid clinical T1 mass were imaged Tc-sestamibi SPECT/CT prior surgical resection. Preoperative scans reviewed by two blinded readers, their results compared centrally pathology data. Following surgery, 6 (12%) classified as 2 (4%) HOCTs. With exception 1 (2%) angiomyolipoma, all cell carcinomas (82%). correctly identified 5 (83.3%) (100%) HOCTs, resulting in an overall sensitivity 87.5% (95% confidence interval [CI], 47.4−99.7%). Only falsely positive on SPECT/CT, specificity 95.2% CI, 83.8−99.4%). summary, is promising test diagnosis Patient summary We found that can be used accurately diagnose types benign kidney This may eventually help better diagnosed tumor.