Development of antibodies against pneumococcal proteins α-enolase, immunoglobulin A1 protease, streptococcal lipoprotein rotamase A, and putative proteinase maturation protein A in relation to pneumococcal carriage and Otitis Media

摘要: Surface associated pneumococcal proteins α-enolase (Eno), immunoglobulin A1 protease (Iga), streptococcal lipoprotein rotamase A (SlrA), and putative proteinase maturation protein (PpmA) have potential as candidates for future protein-based anti-pneumococcal vaccines. The immunogenicity of these were studied in a cohort 329 children during their first two years life. During the recorded episode otitis media, acute convalescent phase sera available from 151 children. Concentrations antibodies against Eno, Iga, SlrA PpmA measured by EIA detected 99% (300/302), 95% (288/302), 83% (251/302) sera, respectively. There no statistically significant differences between groups with without history contact or respect to type contact. Despite mean overall decrease antibody titers following AOM, several able respond more than twofold increase titer response AOM. majority increased concentrations appeared groups, which colonized pneumococci at time serum collection, but having prior pneumococci. In conclusion, SlrA, PpmA, Eno Iga are immunogenic that elicit responses early No correlation carriage infection was found. Presumably, this results presence cross-reactive epitopes on commensal bacteria.