Effect of desferrioxamine and chronic iron deficiency of heme metabolism--comparison with the porphyrogens 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
作者： Heng Liem , Ann Smith , Ursula Muller-Eberhard
DOI: 10.1016/0006-2952(79)90536-7
关键词: Derepression 、 Microsome 、 ATP synthase 、 Substrate (chemistry) 、 Heme 、 Iron deficiency 、 Heme oxygenase 、 Biochemistry 、 Chemistry 、 Heme metabolism
摘要: Abstract Desferrioxamine (DF), an iron chelator, inhibits mitochondrial heme synthase (heme-S) activity and stimulates the of microsomal oxygenase (MHO) in liver rats. However, inhibitory effect on heme-S is not accompanied by increased δ-aminolevulinic acid (ALA-S). Consequently, no prolonged accumulation porphyrins found liver. The proposed mechanism induction ALA-S porphyrogen, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), has been thought to involve first a decrease followed increase activity. DF DDC both inhibit heme-S, but was induced as it DDC. Therefore, concept derepression following decreased production cannot itself explain observed results. they do indicate relationship between metabolism which above that simple reduction substrate availability for formation implicate role regulation heme.
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