Principles Driving the Spatial Organization of Rho GTPase Signaling at Synapses

摘要: The Rho proteins play critical roles in numerous aspects of neuronal development, and mutations their regulators (GEFs GAPs) effectors underlie multiple neurodevelopmental neurological disorders. How GTPase-mediated signaling can have a hand regulating so many different neurobiological processes remains challenging question. An emerging theme is that GAPs GEFs, through spatial/temporal regulation and/or additional protein–protein interactions, cooperate making connections between upstream signals the downstream output, engaging distinct effector proteins. This chapter focuses on recent evidence illustrating modes specialized particularly context synaptic structure, function, plasticity, how dysregulation affects behavioral contributes to disease.