IgG1 and IgG4 Antibody Responses to the Anopheles gambiae Salivary Protein gSG6 in the Sympatric Ethnic Groups Mossi and Fulani in a Malaria Hyperhendemic Area of Burkina Faso

摘要: Human antibody response to the Anopheles gambiae salivary protein gSG6 has recently emerged as a potentially useful tool for malaria epidemiological studies and evaluation of vector control interventions. However, current understanding host immune mosquito proteins possible crosstalk with early Plasmodium parasites is still very limited. We report here analysis IgG1 IgG4 subclasses among anti-gSG6 IgG responders belonging Mossi Fulani from Burkina Faso, two ethnic groups which are known their differential humoral parasite antigens different susceptibility malaria. The against was comparable in groups. On contrary, titers were significantly higher where, addition, antibodies appeared younger children ratio IgG4/IgG1 stayed relatively stable throughout adulthood. Both gSG6-specific showed tendency decrease age whereas, expected, circumsporozoite (CSP) exhibited an opposite trend same individuals. These observations line idea that An. induces tolerance, especially after intense prolonged exposure case area under study, suggesting may trigger exposed individuals Th2-oriented response.