Interleukin-4 and STAT6 promoter polymorphisms but not interleukin-10 or 13 are essential for schistosomiasis and associated disease burden among Nigerian children.

摘要: Abstract Schistosomiasis is endemic in many parts of rural Africa, with previous reports showing interleukin-13 polymorphisms as drivers infectivity and disease severity West Africa while IL-13/IL-4 contributes to patterns reinfection East Africa. We have shown that there a genetic delineation susceptibility infectious diseases addition sub-continental differences pattern. Therefore, which immunoregulatory biomarkers are essential driving S. haematobium infection or regulate burden among Nigerian school children? One hundred thirty one age sex-matched schistosome-infected children 275 uninfected controls, same ethnicity, recruited from southwestern Nigeria, were screened for variability cytokine genes, IL-10 (rs1800872), IL-13 (rs7719175), IL-4 (rs2243250) STAT6 (rs3024974), utilizing polymerase chain reaction-restriction fragment length polymorphism assay. found no difference genotypic allelic frequencies promoter alone association disease. Contrariwise, we report significant the variants between groups. For IL-4, rs2243250 T/T variant was significantly different genotypes (71.6% versus 51.2%; p