Application of pharmacogenomics to vaccines.

摘要: The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research development. A broad range phenotype/genotype data combined with high-throughput genetic sequencing bioinformatics are increasingly being integrated into this emerging vaccinomics. This paper discusses the hypothesis 'immune response gene network' (and bioinformatic) strategies to study associations between immune polymorphisms variations in humoral cellular responses prophylactic viral vaccines, such as measles-mumps-rubella, influenza, HIV, hepatitis B smallpox. Immunogenetic studies reveal new targets by providing better understanding mechanisms which may influence innate adaptive including failure vaccine-associated adverse events. Additional benefits from vaccinomic include development personalized novel vaccines adjuvants.