Serratia Marcescens Outbreak Associated With Extrinsic Contamination of 1% Chlorxylenol Soap

摘要: Objectives:To determine risk factors for Serratia marcescens infection or colonization, and to identify the source of pathogen facilitating its persistence in a neonatal intensive-care unit (NICU) during an outbreak.Design:Retrospective case-control study; review NICU control policies, soap use, hand-washing practices among healthcare workers (HCWs); selected environmental cultures.Setting:A university-affiliated tertiary-care hospital NICU.Patients:All infants with at least one positive culture S August 1994 October 1995. Infants who did not develop colonization were randomly as controls.Results:Thirty-two patients met case definition. On multivariate analysis, independent having very low birth weight (<1,500 g), patent ductus arteriosus, mother chorioamnionitis, exposure single HCW. During January July 1995, HCWs carried their own bottles 1% chlorxylenol soap, which often left standing inverted sink work areas. Cultures 16 (31%) 52 samples 1 (8%) 13 sinks yielded marcescens. The all came from opened 4-oz by HCWs. DNA banding patterns infant, HCW bottle, isolates identical.Conclusions:Extrinsically contaminated contributed outbreak infection. Very-low-birth-weight multiple invasive procedures exposures certain greatest colonization.