Blood pressure regulation determined by ambulatory blood pressure profiles in children and adolescents with type 1 diabetes mellitus: Impact on diabetic complications.

摘要: Background The combination of high blood pressure and hyperglycemia contributes to the development diabetic complications. Ambulatory monitoring (ABPM) is seen as standard assess (BP) regulation. Objective We evaluated 24-hour BP regulation in 3529 children with type 1 diabetes, representing 5.6% patients <20 years age documented DPV registry, studied influence parameters including pulse (PP) variability (BPV) on microalbuminuria (MA) retinopathy (DR). Results BP was increased this selected cohort diabetes compared healthy German controls (standard deviation score (SDS) day: systolic (SBP) +0.06, mean arterial (MAP) +0.08, PP +0.3; night: SBP +0.6, diastolic MAP +0.8), while daytime (SDS −0.2) dipping were reduced (SBP −1.1 SDS, 12.4% vs 19.4%), showed reverse (−0.7 SDS). Children microvascular complications had by +0.1 +0.75 SDS higher parameters, except nocturnal MA diurnal DR. Reverse more pronounced (−5.1% −0.8%) DR (−2.6% −1.0%). alteration stronger girls age. Conclusion There an early close link between not only for systolic, diastolic, but also derived parameter BPV our patients.