Pulse pressure in children and adolescents with type 1 diabetes mellitus in Germany and Austria.

摘要: Background: Impaired blood pressure regulation contributes to the development of diabetic complications. The influence systolic (SBP) vs. diastolic (DBP) is still controversial. Peripheral pulse (PP), difference between SBP and DBP, an indicator for arterial stiffness. Only little data are available PP in children. Therefore, we studied type 1 children adolescents. Methods: Blood values 46737 patients with T1DM younger than 20years documented DPV database were compared control populations '4th report on high (4th report)' German KIGGS study. Results: increased 63% report) or 67% (KIGGS) patients, respectively. rate remains stable 59 68%, irrespective sex, age, population. Absolute elevated independently population (PP 49.13±11.1 4th 45.38±3 44.58±4.6 mmHg; all p<0.0001, Wilcoxon test) increases age both sexes. Age, male diabetes duration, insulin dose, body mass index (BMI) independent factors contributing absolute levels prevalence wide PP. HbA1c negligible negatively related (multiple linear regression). Conclusions: In a marker accelerated stiffness aging should be considered as additional risk factor treatment Elevated may contribute early atherosclerosis.