Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport
作者： Shoko Horita , George Seki , Hideomi Yamada , Masashi Suzuki , Kazuhiko Koike
DOI: 10.4061/2011/391762
关键词:
摘要: Sodium transport through various nephron segments is quite important in regulating sodium reabsorption and blood pressure. Among several regulators of this process, insulin acts on almost all the a strong enhancer reabsorption. Sodium-proton exchanger type 3 (NHE3) main regulator luminal side proximal tubule. In basolateral tubule, sodium-bicarbonate cotransporter (NBCe1) mediates bicarbonate exit from tubular cells. distal connecting epithelial channel (ENaC) great importance to NHE3, NBCe1, ENaC are regulated by insulin. Recently with-no-lysine (WNK) kinases, responsible for familial hypertension, stimulating nephron, have been found be also We will discuss regulation renal its roles pathogenesis hypertension resistance.
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