Endothelial Dysfunction and Increased Arterial Intima-Media Thickness in Children With Type 1 Diabetes
作者： Mikko J. Järvisalo , Maria Raitakari , Jyri O. Toikka , Anne Putto-Laurila , Riikka Rontu
DOI: 10.1161/01.CIR.0000124725.46165.2C
关键词:
摘要: Background— Endothelial dysfunction may play a pathophysiological role in the development of atherosclerosis subjects with type 1 diabetes. We examined whether alterations vascular endothelial function exist children diabetes and tested hypothesis that is associated early structural atherosclerotic changes these children. Methods Results— Noninvasive ultrasound was used to measure brachial artery flow-mediated dilation (FMD) responses carotid intima-media thickness (IMT) 75 (mean age 11±2 years), 45 (diabetes duration 4.4±2.9 years) 30 healthy control Children had lower peak FMD response (4.4±3.4% versus 8.7±3.6%, P<0.001) increased IMT (P<0.001) compared controls. Sixteen (36%) defined as total lowest decile for normal These (0.58±0.05 versus...
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