Early changes of arterial elasticity in Type 1 diabetes with microvascular complications - A cross-sectional study from childhood to adulthood.
作者： P.Z. Benitez-Aguirre , A.S. Januszewski , Y.H. Cho , M.E. Craig , A.J. Jenkins
DOI: 10.1016/J.JDIACOMP.2017.08.007
关键词:
摘要: Abstract Aim To examine the trajectory of small artery elasticity (SAE) and pulse pressure (PP) in people with Type 1 diabetes non-diabetic controls across lifespan, explore associations microvascular complications (CX+). Methods This cross-sectional study included 477 patients (188 CX+, 289 without CX−) 515 controls. Relationships between SAE PP age were evaluated using segmented linear regression. Logistic regression was used to assess (retinopathy and/or nephropathy) PP. Results peaked significantly later among than diabetic CX− vs. CX+ (21.2 20.4 17.6 years respectively, p Conclusion subjects have an earlier peak decline relative controls, who did not differ. Lower higher associated increased odds adults. These clinically applicable techniques demonstrate association accelerated vascular aging diabetes.
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