Hexasomy of chromosome 8 and trisomy of chromosome 11 characterize two karyotypically independent clones in a case of acute non-lymphocytic leukemia: Conventional cytogenetic and FISH investigation☆
作者： Luba Trakhtenbrot , Esther Rosner , Nelly Gipsh , Sarah Berman , Orit Sofer
DOI: 10.1016/0165-4608(95)00107-7
关键词: Genetics 、 Biology 、 Chromosome 、 Aneuploidy 、 Metaphase 、 Fish <Actinopterygii> 、 Trisomy 、 Leukemia 、 Molecular biology 、 Clone (cell biology) 、 Cytogenetics
摘要: A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics FISH. Significant quantitative differences between data obtained metaphase interphase analysis the clone were observed. difference in sensitivity chemotherapy clones found: while markedly decreased response treatment, 11 remained unchanged.
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