The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial.

摘要: Abstract Background Individuals with alcohol use disorder (AUD) do not always respond to currently available treatments, and evaluation of new candidate pharmacotherapies is indicated. N-acetylcysteine (NAC), an over-the-counter supplement, has shown promise in treating a variety substance disorders, but little research evaluated its merits as treatment for AUD. This secondary analysis from the National Drug Abuse Treatment Clinical Trials Network examined effects NAC versus placebo on among participants cannabis (CUD) enrolled 12-week, multi-site cessation trial. Methods Participants (N = 302, ages 18–50) were randomized double-blind (1200 mg, twice daily) or placebo. Neither nor desire requirements participation. that returned at least one visit had recorded data (i.e., total drinks per week, drinking days binge week) included (n = 277). Results Compared group, group increased odds between-visit abstinence [OR = 1.37; 95% CI = 1.06–1.78; p = 0.019], fewer week [RR = 0.67; CI = 0.48–0.99; p = 0.045], [RR = 0.69; CI = 0.51–0.92; p = 0.014]. Changes concurrent amounts correlated any variables. Discussion These findings indicate may be effective reducing consumption by ∼30% treatment-seeking adults CUD, suggesting need further trials focused individuals seeking