Peripheral Nerve Amyloidosis

摘要: Provided is an overview of the pathology, clinically defining features, and subcategorization peripheral nerve amyloidosis. This condition pathologically hallmarked by infiltrative amyloid deposition in varied neural tissue localizations with associated clinical manifestations. Peripheral involvement a frequent presenting feature systemic amyloidosis (Kyle et al., Neuropathies, Saunders, Philadelphia, PA, 2,427–2,451, 2005). As other organ systems, diagnosis often delayed because features may mimic many varieties neuropathy. Therefore, pathologic discovery unsuspected common. The particular protein can determine course preferred treatment modality, as well potentially alert patients to familial predisposition. Advances laboratory technology, including most notably mass spectrophotometric evaluation nerve, continue improve accuracy sensitivity subtyping (Adams, J Neurol 248(8), 2001; Benson Kincaid, Muscle Nerve 36(4), 2007; Klein al. Arch 68(2), 2011). Appropriate directed biopsy therefore be instrumental identifying providing specific type, informing prognosis, directing care each case.