Training ribozymes to switch.
作者： Andrew D. Ellington , Kristin A. Marshall
DOI: 10.1038/14872
关键词: In vitro 、 Group II intron 、 Ligase ribozyme 、 Ribozyme 、 Nucleotide 、 Small molecule 、 Biology 、 Allosteric regulation 、 Biochemistry
摘要: Ribozymes that are sensitive to cyclic nucleotides have been selected in vitro. Remarkably, the cGMP-dependent ribozymes specifically activated by a factor of 5,000 - largest allosteric ribozyme activation small molecule seen date.
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sci-hub.se 参考文章(13)
Otto Meth-Cohn, 香爾 中西, Barton, Derek, Sir, Comprehensive natural products chemistry Elsevier. ,(1999)
Ronald R. Breaker, Makoto Koizumi, Garrett A. Soukup, Jo Nita Q. Kerr, Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP Nature Structural & Molecular Biology. ,vol. 6, pp. 1062- 1071 ,(1999) , 10.1038/14947
Michael P. Robertson, Andrew Ellington, In vitro selection of an allosteric ribozyme that transduces analytes to amplicons Nature Biotechnology. ,vol. 17, pp. 62- 66 ,(1999) , 10.1038/5236
Feng Jiang, R. Ajay Kumar, Roger A. Jones, Dinshaw J. Patel, Structural Basis of RNA Folding and Recognition in an AMP-RNA Aptamer Complex Nature. ,vol. 382, pp. 183- 186 ,(1996) , 10.1038/382183A0
Garrett A Soukup, Ronald R Breaker, Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization Structure. ,vol. 7, pp. 783- 791 ,(1999) , 10.1016/S0969-2126(99)80102-6
R. A. Torres, T. C. Bruice, Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reaction. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 11077- 11082 ,(1998) , 10.1073/PNAS.95.19.11077
Jon R. Lorsch, Jack W. Szostak, In vitro evolution of new ribozymes with polynucleotide kinase activity Nature. ,vol. 371, pp. 31- 36 ,(1994) , 10.1038/371031A0
Jin Tang, Ronald R. Breaker, RATIONAL DESIGN OF ALLOSTERIC RIBOZYMES Chemistry & Biology. ,vol. 4, pp. 453- 459 ,(1997) , 10.1016/S1074-5521(97)90197-6
Norman R. Pace, Terry L. Marsh, RNA catalysis and the origin of life. Origins of Life and Evolution of Biospheres. ,vol. 16, pp. 97- 116 ,(1985) , 10.1007/BF01809465
G. A. Soukup, R. R. Breaker, Engineering precision RNA molecular switches Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 3584- 3589 ,(1999) , 10.1073/PNAS.96.7.3584