Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers
作者： Jian Du , Jing Dai , Jun-Long Liu , Theresa Dankovich
DOI: 10.1016/J.REACTFUNCTPOLYM.2006.01.014
关键词: Differential scanning calorimetry 、 Infrared spectroscopy 、 Kinetics 、 Drug carrier 、 Polyelectrolyte 、 Chromatography 、 Chemistry 、 Chitosan 、 Glucomannan 、 Swelling
摘要: Novel polyelectrolyte beads based on carboxymethyl Konjac glucomannan (CKGM) and chitosan (CS) were prepared via electrostatic interaction. The main advantage of this system is that all procedures used were performed in aqueous medium. The pH-sensitivity of beads was characterized by fourier transformed infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The swelling characteristics of these hydrogel beads at distinct compositions as a function of pH values were investigated. It was found that the swelling rate …
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