Self-assembly of a swollen chitosan/chondroitin sulfate hydrogel by outward diffusion of the chondroitin sulfate chains.
作者： Juliana F. Piai , Adley F. Rubira , Edvani C. Muniz
DOI: 10.1016/J.ACTBIO.2009.03.035
关键词:
摘要: A hydrogel constituted of chitosan (CT) and chondroitin sulfate (CS) was synthesized. In previously reported works the stochiometric ratio has been used, but in this paper an excess CS (40% CT 60% CS) used because could be applied as a carrier. The properties were investigated by differential scanning calorimetry, wide-angle X-ray scattering (WAXS), electron microscopy, high-performance liquid chromatography. Changes pH gel-surrounding had considerable effect on both release molecular reorganization CS. Furthermore, formed exhibited interesting parameters for use biotechnology, such water affinity, thermal morphology upon sequential variation. protonation or deprotonation different groups that participate complex formation coiling uncoiling like unlike chains concomitant to are believed main factors affecting properties. released mainly at higher than 6.5, value pK(aCT), maximum fraction approximately 0.5. WAXS data demonstrated CT/CS presented macromolecular pHs ranging from 6 12.
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