Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb.
作者： J D Roberts , T Y Chen , N Kawai , J Wain , P Dupuy
关键词: Hypoxic pulmonary vasoconstriction 、 Internal medicine 、 Lung 、 Vasoconstriction 、 Acidosis 、 Respiratory acidosis 、 Cardiology 、 Anesthesia 、 Hypoxia (medical) 、 Nitric oxide 、 Medicine 、 Vasodilation
摘要: We determined whether inhaling low levels of nitric oxide (NO) gas could selectively reverse hypoxic pulmonary vasoconstriction in the near-term newborn lamb and vasodilation would be attenuated by respiratory acidosis. To examine mechanism air NO-induced soon after birth, we measured plasma lung cGMP newly ventilated fetal lamb. Breathing at FIO2 0.10 nearly doubled vascular resistance index lambs decreased blood flow primarily reducing left-to-right through ductus arteriosus. Inhaling 20 ppm NO completely reversed within minutes. Maximum occurred during inhalation > or = 80 NO. 8% CO2 elevated to a level similar breathing without added CO2. Respiratory acidosis did not attenuate inhaled In none our studies produce systemic hypotension elevate methemoglobin levels. Four minutes initiating ventilation with lung, concentration changing preductal concentration. Ventilation 0.21 increased both threefold. Our data suggest that is rapid potent selective vasodilator circulation an tone due hypoxia acts increasing
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