Posterior cerebral atrophy in the absence of medial temporal lobe atrophy in pathologically-confirmed Alzheimer's disease

摘要: Medial temporal lobe atrophy (MTA) is a recognized marker of Alzheimer's disease (AD), however, it can be prominent in frontotemporal lobar degeneration (FTLD). There an increasing awareness that posterior (PA) important AD and may aid the differentiation from FTLD. Visual rating scales are convenient way assessing clinical setting. In this study, 2 visual measuring MTA PA were used to compare patterns 62 pathologically-confirmed 40 FTLD patients. Anatomical correspondence was assessed using manually-delineated regions hippocampus cingulate gyrus, respectively. Both showed good inter- intrarater reliabilities (kappa > 0.8). scores with manual hippocampal volumes. Thirty percent patients absence MTA. Adding scale improved discrimination FTLD, early-onset normal aging. These results underline importance considering diagnosis, particularly younger where medial less conspicuous.