Fli-1 expression in malignant melanoma.
作者： John F DeCoteau , Nurija Bilalovic , Vivi Ann Flørenes , Ana Slipicevic , Richa Chibbar
DOI: 10.14670/HH-23.1309
关键词: Melanoma 、 Immunohistochemistry 、 Blot 、 Primary tumor 、 Friend leukemia 、 Immunocytochemistry 、 Cell growth 、 Pathology 、 Medicine 、 Western blot
摘要: Friend leukemia integration site 1 (Fli-1) has been reported as the first nuclear marker of endothelial differentiation; it is expressed in leukocytes and recently demonstrated melanomas. Formalin-fixed, paraffin-embedded tissue sections from 97 melanomas including 69 cases primary 28 metastatic were evaluated by immunohistochemistry. Five melanoma cell lines Western blot immunocytochemistry. Fli-1 expression was observed all lines. higher than tumors (r=0.208, p=0.041, Spearman correlation), positively correlated with Ki-67 (r=0.233, p=0.022, presence an ulcer tumor (r=0.267, p=0.030, correlation). Therefore, malignant appears to be associated biologically more aggressive tumors.
unirioja.es
um.es
sci-hub.st 参考文章(22)
Øystein Fodstad, Alexander Pihl, Inge Kjønniksen, Jahn M. Nesland, Steinar Aamdal, Michael R. Boyd, Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells. Cancer Research. ,vol. 48, pp. 4382- 4388 ,(1988)
McCarty Ks, Cox Eb, Miller Ls, Konrath J, Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Archives of Pathology & Laboratory Medicine. ,vol. 109, pp. 716- 721 ,(1985)
Ki-Baik Hahm, Keuna Cho, Cecile Lee, Young-Hyuck Im, Jay Chang, Shin-Geon Choi, Poul H.B. Sorensen, Carol J. Thiele, Seong-Jin Kim, Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nature Genetics. ,vol. 23, pp. 222- 227 ,(1999) , 10.1038/13854
Robert Hromas, William May, Christopher Denny, Wendy Raskind, Jason Moore, Richard A. Maki, Edmund Beck, Michael J. Klemsz, Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neuroepithelioma Biochimica et Biophysica Acta. ,vol. 1172, pp. 155- 158 ,(1993) , 10.1016/0167-4781(93)90283-J
V Dulic, E Lees, S. Reed, Association of human cyclin E with a periodic G1-S phase protein kinase. Science. ,vol. 257, pp. 1958- 1961 ,(1992) , 10.1126/SCIENCE.1329201
Isabelle Schwartz-Cornil, I Cornil, D Theodorescu, S Man, M Herlyn, J Jambrosic, R Kerbel, Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 6028- 6032 ,(1991) , 10.1073/PNAS.88.14.6028
W. A. May, M. L. Gishizky, S. L. Lessnick, L. B. Lunsford, B. C. Lewis, O. Delattre, J. Zucman, G. Thomas, C. T. Denny, Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 5752- 5756 ,(1993) , 10.1073/PNAS.90.12.5752
Fumihiko Nakatani, Kazuhiro Tanaka, Riku Sakimura, Yoshihiro Matsumoto, Tomoya Matsunobu, Xu Li, Masuo Hanada, Takamitsu Okada, Yukihide Iwamoto, None, Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein Journal of Biological Chemistry. ,vol. 278, pp. 15105- 15115 ,(2003) , 10.1074/JBC.M211470200
Andrew L. Folpe, Eric M. Chand, John R. Goldblum, Sharon W. Weiss, Expression of Fli-1, a Nuclear Transcription Factor, Distinguishes Vascular Neoplasms From Potential Mimics The American Journal of Surgical Pathology. ,vol. 25, pp. 1061- 1066 ,(2001) , 10.1097/00000478-200108000-00011
Sabrina Rossi, Enrico Orvieto, Alberto Furlanetto, Licia Laurino, Vito Ninfo, Angelo P Dei Tos, Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody. Modern Pathology. ,vol. 17, pp. 547- 552 ,(2004) , 10.1038/MODPATHOL.3800065