Association of human cyclin E with a periodic G1-S phase protein kinase.
作者： V Dulic , E Lees , S. Reed
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摘要: G1 cyclins control the to S phase transition in budding yeast, Saccharomyces cerevisiae. Cyclin E was discovered course of a screen for human complementary DNAs that rescue deficiency cyclin function yeast. The amounts both protein and an associated kinase activity fluctuated periodically through cell cycle; were maximal late early phases. E-associated correlated with appearance complexes containing cyclin-dependent Cdk2. Thus, E-Cdk2 complex may constitute G1-S phase-specific regulatory kinase.
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